Here are two little articles I picked up concerning defense against individuals armed with knifes and knife wounds.
Facing an edged weapon...
While it is an article concerning defense against knifes when armed with a firearm it provides a fair amount of useful information on what a knife is capable of.
"Indiana Jones" had the right idea
Disclaimer: This picture contains some really nasty pictures of somewhat nasty knife wounds. If you are underage or possess a weak stomach I suggest you do not click on the link. Ye have been warned...

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Thank you for the unadulterated realism and reality check there Sanchez. I think for this site it is/was well needed.
"They drew first blood not me..." (Stallone in Rambo: First Blood)

No problamo. The lates trench knife topic got me thinking about it. Wonder if anyone is going to doubt the effectiveness of a regular blade when comparing it to what's basically a spike.
AS my little addition, this is another reason to study a martial art such as my personaly favourite HapKiDo or Ninjitsu, both teach excellent knife fighting and knife defense.
Or you can take a dedicated knife fighting class based on the classic William Fairbairn method.
Also, DO NOT BUY A "Learn ____ at home" DVD, YOU CAN NOT LEARN MUSCLE MEMORY BY WATCHING A DVD.